ChemNet > CAS > 920509-32-6 1,2,4-Triazine-6-carbonitrile,2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-

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920509-32-6 1,2,4-Triazine-6-carbonitrile,2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-

product Name	1,2,4-Triazine-6-carbonitrile,2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-
CAS No	920509-32-6
Synonyms	MGL-3196; 2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile; Resmetirom
Molecular Formula	C₁₇H₁₂Cl₂N₆O₄
Molecular Structure

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Description	Product name: Resmetirom Resmetirom; MGL-3196; 920509-32-6; VIA-3196; 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3 ,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile; MGL 3196; Resmetirom [USAN]; MGL3196; RE0V0T1ES0 CAS No. 920509-32-6 Molecular Formula: C17H12Cl2N6O4 Molecular weight: 435.22 EINECS number: Density: 1.65??0.1g/cm3(Predicted) Storage condition: Inertatmosphere,Storeinfreezer,under-20??C Solubility: DMSO: 59.0 (maximum concentration mg/mL); 135.56 (maximum concentration mM) Form: Crystalline solid Acidity coefficient: (pKa)3.96??0.40(Predicted) Characteristics: light yellow solid powder Product Use: BioactivityResmetirom (MGL-3196,VIA-3196) is a hepatic-directed, orally active, selective thyroidhormonereceptor??(THR-??) agonist with an EC50 of 0.21 ??M and a 28-fold selectivity for THR-?? over THR-??. MGL-3196 has been tested for the treatment of non-alcoholic steatohepatitis and heterozygous familial hypercholesterolemia. Prod...
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