Dimethylphosphine oxide

• Category :

  Intermediates/Pharmaceutical intermediates

• Synonyms :

  dimethyl(oxo)phosphonium;dimethylphosphane oxide;

• CAS NO :

  7211-39-4

• EC NO :

  230-591-2

• Molecular Formula :

  C₂H₇OP

• Molecular Weight :

  78.0501

• Main Specifications :

  99% min

• InChI :

  InChI=1/C2H7OP/c1-4(2)3/h4H,1-2H3

• Packing :

  25kg，50kg 200kg

• Product description :

  What is the chemical of Dimethylphosphine oxide ? Appearance: Colorless to pale yellow liquid ; Assay：99%min by GC ; IR Identity: conform to standard ; HNMR： conform to standard ; carbon spectrum: conform to standard ; Water by K. F.:0.5% max or as per the customer’s request ; Loss on drying:0.5% max. or as per the customer’s request ; Melting point: 65-67 °C; ============================================================================== In terms of applications, dimethyl phosphine oxide is mainly used as an organic synthesis intermediate in the fields of medicine, pesticides, and chemical engineering, such as for the synthesis of organosilicon compounds or as a catalyst; Its downstream products include specific amino phenyl derivatives, which are commonly used as reagents in scientific research and industrial production ============================================================================ The main synthetic routes include Grignard reagent method and halogenated hydrocarbon method. Specifically: Grignard reagent method: Using diethyl phosphite as the phosphorus source, react with methyl magnesium chloride (Grignard reagent) at low temperature, and undergo addition and hydrolysis steps to generate dimethyl phosphine oxide with a yield of about 80%. This method requires strict anhydrous conditions to avoid side reactions. Halogenated hydrocarbon method: Chloromethane reacts with diethyl phosphite under the action of a catalyst, with a low yield (about 5%), and usually requires optimization of the catalyst to improve efficiency. Other routes may involve selective oxidation of dimethylphosphine, but there are few literature reports on this

• Uses :

  as an organic synthesis intermediate

• Molecular Structure :