2-(2-Methoxyethoxy)ethyl chloride

• Category :

  Intermediates/Pharmaceutical intermediates

• Synonyms :

  1-(2-Chloroethoxy)-2-methoxyethane;1-chloro-2-(2-methoxyethoxy)ethane;

• CAS NO :

  52808-36-3

• EC NO :

• Molecular Formula :

  C₅H₁₁ClO₂

• Molecular Weight :

  138.5926

• Main Specifications :

  99% min

• InChI :

  InChI=1/C5H11ClO2/c1-7-4-5-8-3-2-6/h2-5H2,1H3

• Packing :

  25kg，50kg 200kg

• Product description :

  What is the chemical of 2-(2-Methoxyethoxy)ethyl chloride ? Appearance: colorless clear liquid ; Assay：99%min by GC ; IR Identity: conform to standard ; HNMR： conform to standard ; carbon spectrum: conform to standard ; Water by K. F.:0.5% max or as per the customer’s request ; Loss on drying:0.5% max. or as per the customer’s request ; boiling point: 156–169℃（760 mmHg）; =============================================================================== main purpose Research reagents: widely used in laboratory organic synthesis research as reaction intermediates or protective group introducers. Organic synthesis intermediates: Used for synthesizing drug molecules containing ether bonds, such as precursors of antiviral or anti-tumor compounds. It can be used as a chloroethylation reagent to participate in nucleophilic substitution reactions and construct C-O-C-Cl structural units. Used in polymer chemistry to modify polyether segments and enhance the hydrophilicity or reactivity of materials. Potential application areas: Pharmaceutical industry: as a precursor for the synthesis of azilsartan intermediates. Electronic chemicals: used for preparing high-purity solvents or functionalized surface treatment agents. This compound has not been found in the field of large-scale industrial consumption and is mainly used for scientific research and small-scale customized synthesis. ============================================================================= There are several main synthetic routes: Using diethylene glycol monomethyl ether as raw material, the target product can be obtained with high yield (about 94%) through chlorination reaction. This is one of the most efficient methods reported in the literature. The synthesis of dichloroethyl ether and sodium methoxide through nucleophilic substitution reaction is a classic preparation method. Using dichloroethyl ether and diethylene glycol monomethyl ether as raw materials, the reaction is carried out under acidic conditions (such as using 4-methylbenzenesulfonic acid), but the yield is relatively low (about 49%). Using 2- (2-methoxyethoxy) ethyl-4-methylbenzenesulfonic acid ester as raw material: prepared by replacing the sulfonic acid ester group with chloride ions. These routes all start with alcohols or ethers containing ether bonds and synthesize target molecules by introducing chlorine atoms. The specific choice of route depends on the availability of raw materials, cost, and requirements for yield and purity

• Uses :

  Used for synthesizing drug molecules containing ether bonds

• Molecular Structure :