b-chlorophenetole
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- Category :
Intermediates/Pharmaceutical intermediates
- CAS NO : 622-86-6
- EC NO : 210-757-0
- Molecular Formula : C8H9ClO
- Main Specifications : 99% min
- Synonyms : Benzene, (2-chloroethoxy)-;2-chloroethyl phenyl ether;
Package: 25kg，50kg 200kg
Uses : As a pharmaceutical intermediate, used for synthesizing the following drugs
Molecular Structure:
Product description:
What is the chemical of b-chlorophenetole?
Appearance: Colorless to pale yellow transparent oily liquid ;
Assay：99%min by GC ;
IR Identity: conform to standard ;
HNMR： conform to standard ;
carbon spectrum: conform to standard ;
Water by K. F.:0.5% max or as per the customer’s request ;
Loss on drying:0.5% max. or as per the customer’s request ;
boiling point: 217–220 °C ;
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main purpose
As a pharmaceutical intermediate, used for synthesizing the following drugs:
The anthelmintic insecticide Miechon Ning;
Antidepressant naphthoprim.
Can react with dimethyl-amine to produce the intermediate phenoxyethyldimethyl-amine.
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synthetic route
Mainly prepared through the following two methods:
1. Phenol reacts with dichloroethane under high pressure conditions:
Mix phenol, sodium hydroxide solution, and water to form sodium phenolate;
Add dichloroethane and react for 3 hours at 130 ° C and 0.75-0.88 MPa;
After the reaction, cool, wash, layer, evaporate the solvent, and distill to obtain the product.
2. Reaction of o-chlorophenol with diethyl sulfa
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