Methyl nicotinate
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- Category :
Organic chemicals and Derivatives/Aroma compounds
- CAS NO : 93-60-7
- EC NO : 202-261-8
- Molecular Formula : C7H6NO2
- Main Specifications : 99% min
- Synonyms : Methyl pyridine-3-carboxylate;Nicotinic acid methyl ester;2-methylpyridine-3-carboxylate;3-Picolinic Acid Methyl Ester;
Package: 25kg 50kg drum or bag
Uses : Methyl nicotinate is used as an intermediate in the fields of pharmaceuticals, food additives, and cosmetics.
Molecular Structure:
Product description:
What is the chemical of Methyl nicotinate ?
Appearance: White to pale yellow crystalline powder；
Assay:99%min by HPLC；
IR Identity: conform to standard；
HNMR： conform to standard；
carbon spectrum: conform to standard；
Water by K. F.:0.5% max or as per the customer’s request；
Loss on drying:0.5% max. or as per the customer’s request；
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Methyl nicotinate Applications:
Medicine: Used as a component in topical preparations to relieve muscle and joint pain; it has skin permeability and vasodilatory effects.
Chemical Intermediate: Used in the synthesis of organic compounds such as silver(I) complexes and 5-aryl nicotinates.
Food Additive: Acts as a flavor enhancer for food.
Cosmetic Ingredient: Possesses soothing and astringent properties.
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The main synthesis methods include the following:
Direct Esterification:
Nicotinic acid reacts with methanol in an acidic catalyst (such as concentrated sulfuric acid) to undergo esterification:
Nicotinic acid + Methanol → Methyl nicotinate + Water
The reaction conditions are typically reflux, with a molar ratio of nicotinic acid to methanol of approximately 1:1.2–2.
From Pyridine Derivatives:
Using 3-cyanopyridine as the starting material, it is hydrolyzed to produce nicotinic acid, which is then esterified to obtain methyl nicotinate.
Efficient processes such as microwave-assisted synthesis or catalytic hydrogenation are employed, and some methods achieve a yield of up to 98% (for reference only).
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