6-Methoxy-1-Tetralone
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- Category :
Intermediates/Pharmaceutical intermediates
- CAS NO : 1078-19-9
- EC NO : 214-078-0
- Molecular Formula : C11H12O2
- Main Specifications : 99% min
- Synonyms : 3,4-Dihydro-6-methoxy-1(2H)-naphthalenone;6-methoxy-1,2,3,4-tetrahydronaphthalen-1-one;6-Methoxy-1-Tetralon;6-Methoxy–α-tetralone;6-Methoxytetralone;6-methoxy-3,4-dihydronaphthalen-1(2H)-one;
Package: 25kg 50kg drum or bag
Uses : Mainly used as an intermediate for steroid hormone drugs,
Molecular Structure:
Product description:
What is the chemical of 6-Methoxy-1-Tetralone ?
Appearance: Light yellow to light brown crystalline powde ;
Assay: 99% min by HPLC ;
IR Identity: conform to standard ;
HNMR： conform to standard ;
carbon spectrum: conform to standard ;
Water by K. F.:0.5% max or as per the customer’s request ;
Loss on drying:0.5% max. or as per the customer’s request ;
Melting point: 77–79 °C;
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purpose
Mainly used as an intermediate for steroid hormone drugs, such as:
18 Methyl Norethinyl Ketone
Triene ketone
Dixolone
Also used for the synthesis of family planning drugs
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synthetic route
The main synthesis methods are as follows:
Using tetrahydronaphthalene methyl ether as raw material, the following is obtained through oxidation reaction:
Mix tetrahydronaphthalene methyl ether with water and cool;
Slowly add potassium permanganate sulfuric acid solution under vigorous stirring, and control the temperature at 40-45 ℃;
After adding, keep warm and react for 2 hours;
Let it settle and separate into layers, then release the acidic water from the lower layer;
Cool with water to below 0 ℃ and filter;
Wash the filter cake with sodium hydroxide solution until neutral;
Dried product (6-methoxy-1-naphthoquinone).
Other oxidants can be chromium oxide in pyridine hydrochloride.
The preparation pathway of tetrahydronaphthalene methyl ether includes:
Tetrahydronaphthalene → sulfonation → alkali melting → methylation;
β - naphthol → reduction → methylation;
Multiple reactions including benzyl ether → acylation → reduction → cyclization → oxidation, etc
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