2-Phenoxyethylbromide
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- Category :
Intermediates/Pharmaceutical intermediates
- CAS NO : 589-10-6
- EC NO : 209-634-4
- Molecular Formula : C9H11Br
- Main Specifications : 99% min
- Synonyms : 2-Bromoethyl phenyl ether;2-Phenoxyethylbromide;beta-Bromoethyl phenyl ether;Benzene, (2-bromoethoxy)-;(2-bromoethoxy)benzene;(3-bromopropyl)benzene;β-Bromophenetole;1-bromo-2-phenoxyethane;
Package: 25kg，50kg 200kg
Uses : Pharmaceutical intermediates
Molecular Structure:
Product description:
What is the chemical of 2-Phenoxyethylbromide?
Appearance: White to light yellow powder ;
Assay: 99% min by HPLC ;
Solubility: insoluble in water;Easy to dissolve in ethanol, ether, chloroform, and ethyl acetate
IR Identity: conform to standard ;
HNMR： conform to standard ;
carbon spectrum: conform to standard ;
Water by K. F.:0.5% max or as per the customer’s request ;
Loss on drying:0.5% max. or as per the customer’s request ;
Melting point: 31–34?°C;
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main purpose
Pharmaceutical intermediates used for synthesizing the following drugs:
Nefazodone
Nucleophilic substitution precursors widely used in organic synthesis
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synthetic route
Mainly prepared by reacting phenol with 1,2-dibromoethane under alkaline conditions:
Mix phenol, 1,2-dibromoethane, and sodium hydroxide;
Stir the reaction at 110 ° C for 6 hours;
Recovery of unreacted dibromoethane (with a recovery rate of approximately 60%);
Wash the reaction mixture with 5% NaOH solution and water;
Separate the oil layer, perform vacuum distillation, and collect the 130-150 ° C/6.7 kPa fraction to obtain the product
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