2-Methoxy pyridine
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- Category :
Organic chemicals and Derivatives/Aroma compounds
- CAS NO : 1628-89-3
- EC NO : 216-623-8
- Molecular Formula : C6H7NO
- Main Specifications : 99% min
- Synonyms : Methyl 2-pyridyl ether;2-methoxy pyridine;
Package: 25kg，50kg 200kg
Uses : used as an intermediate in organic synthesis
Molecular Structure:
Product description:
What is the chemical of 2-Methoxy pyridine?
Appearance: Colorless to pale yellow transparent liquid ;
Assay：99%min by GC ;
IR Identity: conform to standard ;
HNMR： conform to standard ;
carbon spectrum: conform to standard ;
Water by K. F.:0.5% max or as per the customer’s request ;
Loss on drying:0.5% max. or as per the customer’s request ;
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Usage: 2-methoxypyridine is mainly used as an intermediate in organic synthesis, especially in the pharmaceutical industry and spice synthesis. It can be used to prepare other pyridine derivatives, such as 6-methoxy-3-pyridinecarboxaldehyde, etc
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Synthetic route
2-Methoxypyridine can be prepared by three main methods:
Synthesis method Reaction conditions Key reagents Literature support
Nucleophilic substitution method Copper salt catalysis, heating 2-halopyridine + sodium methoxide
Reductive methoxylation method Magnesium powder/methanol system 2-halopyridine + Mg/CH?OH
Palladium catalyzed coupling method Pd catalyst, Suzuki type reaction 2-halopyridine + methoxyboronate
Note: In industry, the nucleophilic substitution method is preferred because of its low cost and high yield (>85%).
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