2-Hydroxypyridine
-
- Category :
Organic chemicals and Derivatives/Aroma compounds
- CAS NO : 142-08-5
- EC NO : 205-520-3;276-824-1
- Molecular Formula : C5H5NO
- Main Specifications : 99% min
- Synonyms : 2(1H)-Pyridone;2-pyridone;2-Pyridinol; Pyridin-2-ol;2-Hydroxy Pyridine;pyridin-2(1H)-one;
Package: 25kg 50kg drum or bag
Uses : As an endogenous metabolite, used for peptide synthesis
Molecular Structure:
Product description:
What is the chemical of 2-Hydroxypyridine?
Appearance: White to pale yellow crystals ;
Solubility:
Easily soluble in water (450 g/L, 20 ° C) and ethanol;
Slightly soluble in benzene and ether;
Almost insoluble in petroleum ether and hexane
Assay: 99% min by HPLC ;
IR Identity: conform to standard ;
HNMR： conform to standard ;
carbon spectrum: conform to standard ;
Water by K. F.:0.5% max or as per the customer’s request ;
Loss on drying:0.5% max. or as per the customer’s request ;
Melting point: 105–107 °C;
boiling point: 280-281 ° C (atmospheric pressure);
=============================================================================
Purpose:
Biological activity: As an endogenous metabolite, used for peptide synthesis
Organic synthesis:
As a pharmaceutical intermediate, for example, used in the synthesis of levetiracetam impurity reference substance
Used for catalyzing the reaction of cyclic carbonates with alcohols to produce β - oxopropyl carbonates
Can participate in [4+2] cycloaddition reactions due to its dual nucleophilic properties
Industrial applications: Used for the synthesis of dyes (such as Reactive Yellow M-7G), pesticides, and polymer materials
=============================================================================
Synthetic route
The industrial preparation method is not detailed in the public information, but the following information is available for reference:
Recrystallization purification: Pure product can be obtained by refluxing decolorization at 181-185 ° C/24 mmHg, followed by recrystallization in solvent systems such as ethanol, chloroform/ether, benzene/hexane, etc; It can also be combined with sublimation method
Search Product